Synthesis of the novel analogues of dysidiolide and their structure-activity relationship

M Takahashi; K Dodo; Y Sugimoto; Y Aoyagi; Y Yamada; Y Hashimoto; R Shirai

doi:10.1016/s0960-894x(00)00527-8

Synthesis of the novel analogues of dysidiolide and their structure-activity relationship

Bioorg Med Chem Lett. 2000 Nov 20;10(22):2571-4. doi: 10.1016/s0960-894x(00)00527-8.

Authors

M Takahashi¹, K Dodo, Y Sugimoto, Y Aoyagi, Y Yamada, Y Hashimoto, R Shirai

Affiliation

¹ Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan.

PMID: 11086732
DOI: 10.1016/s0960-894x(00)00527-8

Abstract

The novel analogues of natural cdc25A inhibitor dysidiolide were synthesized. To investigate the structure-activity relationship, the inhibitory activity to enzyme and cell cycle was examined.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

4-Butyrolactone / analogs & derivatives*
4-Butyrolactone / chemical synthesis*
4-Butyrolactone / chemistry
4-Butyrolactone / pharmacology
Cell Cycle / drug effects
Enzyme Inhibitors / chemical synthesis*
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology
Structure-Activity Relationship
cdc25 Phosphatases / antagonists & inhibitors

Substances

Enzyme Inhibitors
cdc25 Phosphatases
dysidiolide
4-Butyrolactone